For contract research organizations (CROs) and analytical laboratories involved in chemical safety assessment, evaluating the potential of substances to induce ocular irritation is a critical endpoint. This evaluation is comprehensively described in OECD Test Guideline 437, which outlines the procedures for the Bovine Corneal Opacity and Permeability (BCOP) test method.
Designed specifically for the BCOP test and fully aligned with the updated OECD TG 437 (June 2025), the Peira LLBO 180 brings a new level of comprehensiveness to in vitro eye irritation testing. By scanning the entire corneal surface, including peripheral regions often missed by conventional systems, the LLBO 180 improves test reliability and interpretability. In identifying Category 1 (serious eye damage) substances, the LLBO 180 performs on par with the OP-KIT, achieving 78% accuracy while slightly reducing false positives (from 25% to 21%). For No Category (non-irritants) classifications, it offers a substantial leap forward: accuracy increases from 68.9% to 82.8%, and false positives decrease markedly from 68.5% to 45%. Backed by official validation, the Peira LLBO 180 stands out as a proven and comprehensive solution for modern BCOP testing.
The revised OECD Test Guideline 437 explicitly references the Peira LLBO as a well-supported and validated instrument, underpinned by extensive inter-laboratory data and regulatory acceptance. This robust evidentiary foundation mitigates the operational and regulatory risks typically associated with the adoption of new analytical instrumentation, thereby providing a high degree of assurance for laboratories investing in the LLBO 180 platform.
Advancing Ocular Safety Testing: VITO and the Peira LLBO 180
VITO, the Flemish Institute for Technological Research, drives innovation in sustainable technologies through close collaboration with industry. One standout example is the Peira LLBO 180 — a powerful demonstration of how VITO combines scientific excellence with strong industry collaboration to de-risk and enable safer products, better regulation, and a future without animal testing
We are proud to recognize Sandra Verstraelen, Principal Researcher at VITO, for her key contributions to the development and scientific validation of the Peira LLBO 180. With extensive expertise in regulatory toxicology and development in New Approach Methodologies, Sandra has been a driving force in aligning the LLBO technology with the OECD Test Guideline 437 for the BCOP assay.
Her work has ensured that the LLBO 180 meets the highest standards and regulatory compliance—making it a trusted tool for laboratories worldwide.
Designed for Simplicity and Confidence
The Peira LLBO 180 is engineered for straightforward operation, making it accessible to both experienced analysts and laboratories new to BCOP testing. From calibration to data interpretation, the system is intuitive and fully aligned with regulatory expectations.
To further support users, Peira Scientific Instruments offers expert guidance and training in collaboration with VITO—either remotely or on-site—ensuring that every lab can implement the LLBO 180 with confidence and precision.
Holiday Sales Action: 12% Off the Peira LLBO 180 – Until December 23, 2025
This summer, Peira Scientific Instruments is making it easier than ever to upgrade your BCOP testing capabilities. For a limited time, we’re offering a 12% discount on all orders of the Peira LLBO 180 placed before October 1, 2025.
Why Choose the LLBO 180?
- Fully aligned with the updated OECD Test Guideline 437
- Designed for detecting subtle and peripheral opacity for more precise and comprehensive results
- Ease of use
- Backed by scientific validation and expert support
- Ideal for CROs, regulatory labs, and academic research centers
A Smart Investment, Now Even Smarter
Whether you’re setting up a new BCOP testing platform or replacing legacy equipment, this is the perfect opportunity to invest in a validated, future-proof solution—with significant savings.
Need Guidance? We’ve Got You Covered
Peira Scientific Instruments offers expert training and support to help your team get started quickly and confidently. From installation to data interpretation, we’re here to ensure your success.
More info
Download the product information brochure or contact us for more information or your personalized LLBO Summer Action offer.