In the European Union, tests for eye irritation and corrosion are mandatory for the approval of cosmetic products, chemicals, and pharmaceuticals. These tests must comply with the guidelines of the REACH regulation (Registration, Evaluation, Authorization, and Restriction of Chemicals) and the CLP regulation (Classification, Labeling, and Packaging of substances and mixtures).
The Laser Light-Based Opacitometer (LLBO) is a validated device used to measure the opacity of substances in the Bovine Corneal Opacity and Permeability (BCOP) Test Method in accordance with OECD Test Guideline 437. This in vitro method is used to evaluate the potential of substances to cause serious eye damage or irritation.
The OECD Test Guideline 437 describes the BCOP Test Method for Identifying Ocular Corrosives and Severe Irritants, thereby reducing and refining the number of in vivo Rabbit Eye Irritation tests. In 2020, the Test Guideline was updated to allow the use of a Laser Light-Based Opacitometer (LLBO) which was shown to have improved performance over the OP-KIT opacitometer used in the validation of the BCOP test method (https://doi.org/10.1787/9789264203846-en).
Features
- OECD Approval: The Peira LLBO 180 is a validated device used for BCOP testing (OECD Test Guideline 437)
- Mandatory Compliance: One of three opacitometers required by OECD Test Guideline 437
- Replacement for OP-KIT: Alternative for OP-KIT and Duratec
- Comprehensive Analysis: Analyzes the entire corneal surface
- Updated Holders: The internal chamber diameter of the support for LLBO holders is 18 mm, while for OP-KIT, it is 17 mm.
- Advanced Equipment: Equipped with a class 3R green laser and standard certified glass filters for calibration
Why Peira LLBO 180?
- OECD Test Guideline 437 Compliance: Fully complies with the OECD Test Guideline 437, confirming its reliability and effectiveness in ocular irritation testing
- Stand-Alone Instrument: Operates independently
- User-Friendly: Easy to use
- Enhanced Detection: Better detection of opaque spots around the periphery of the corneas
- Accurate Assessment: Provides a more accurate definition of the eye-irritating potential of compounds
- Precise Ranking: Offers more precise ranking of moderate to mild and non-irritating compounds
- Regulatory Compliance: Ensures adherence to OECD Test Guideline 437
- Ethical Testing: Supports non-animal testing methods
The Peira LLBO 180 enables improved detection of opaque spots around the periphery of the corneas
Sandra Verstraelen, Senior Researcher, Vito NV
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