Pharmaceutical development

PrillDrop

PrillDrop The Peira PrillDrop is a custom-made prilling equipment to conduct formulation experiments on laboratory scale. After melting the fatty acid and heating the melt to 90 respectively 100 ° C, the active molecule is added to the melt under stirring. Droplet formation starts after complete dissolution of the drug in the molten matrix (e.g. stearic or behenic acid). By applying air pressure to, the mixture is fed toward the thermostated nozzle equipped with a valve and a needle. Drop time and air pressure are set in function of the targeted formulation in order to have consistent and uniform droplet formulation.
After droplet formation at needle end, the ‘prills’ are quench cooled in liquid nitrogen in order to obtain solid spherical particles.

Vervaeck, A.; Saerens, L.; De Geest, B.G.; De Beer, T.; Carleer, R.; Adriaensens, P.; Remon, J.P.; Vervaet, C. (2013). Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms, Eur. J. Pharm. Biopharm. 85 (2013) 587-596

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NanoSizer

PrillDropThe NanoSizer is a high throughput platform consisting of 10 individual small scale media mills assembled in one platform operating in parallel. Individually driven micro motors agitate a rotor in commercially available glass vials filled with the dispersion containing attrition milling media and the product to be milled.
Milling speeds and duration time can be set per individual vial in order to search for the optimal process. A specific designed sealing ring on the shaft of the rotor assures no leakage or loss of material whilst not creating contamination of the dispersion. Special attention has been given to the mechanical design of rotors, shaft and holders in order to allow easy maintenance and cleaning of the apparatus.
This platform enhances the performance of the research lab significantly.  
 

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HumanShaker

humanshakerContent uniformity is required for most dosage forms including suspensions for oral, injectable and ophthalmic administration of drugs. If settling occurs, suspensions must be re-dispersed (by shaking). Until now there has been no apparatus which standardises the pre-handling re-dispersing instructions.

Peira's HumanShaker imitates the human shaking behaviour and provides a standardised method for the re-dispersion of pharmaceutical suspensions. The lateral movement has a radius of approximately 300 mm and the drive belt on which a universal holder is fixed can operate at frequencies up to 5 Hz.

The HumanShaker is designed and manufactured according to pharmaceutical GMP guidelines.

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RollerMill

rollermillPeira's RollerMill is a simple but versatile three-roll apparatus on which you can put different size vials, tubes and flasks. The middle roll drives the system, and you can set the position of the three rolls to the most suitable position.

You can also set drive roll speed to the desired level for your particular experiment.

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NitrogenDryer

Peira's NitrogenDryer is developed to meet the specifications of the DoE (Design of Experiment) that you want to execute. The apparatus hardware and its automation software is linked to your analytical software and enables the pressure of the fluidized bed drying conditions to be simulated.

Easy setting of different pressure, temperature and flow parameters is a critical design parameter of the apparatus. The NitrogenDryer allows you to better understand the critical parameters for the design of full-scale dynamic manufacturing, resulting in reduced downtime, less loss of expensive ingredients, higher productivity and superior quality of the manufacturing equipment to be built.

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PlateClamp

plateclamp Many different types of well plates are used in pharmaceutical and chemical research. Well plates are typically filled with organic solvent mixtures and are processed at elevated temperatures. To prevent evaporation, well plates are sealed, covered and put into a pressure clamping device before being placed into a shaking incubator.

The depth of the plates can vary in function of the well volume or plates can be stacked on one another. Pressure is exerted by screwing the bolts over a long stem that is long enough to cover all the different possible combinations. Researchers know that opening and closing the compression device can be tiresome and time-consuming when the bolt has to be screwed down to its lowest position (for example to hold a single 0.5 ml well plate). Multiple plates housed in multiple compression devices are processed simultaneously.

Peira's PlateClamp significantly reduces the time needed for clamping. It's an easy-to-use tool with specially designed bolts. The bolts slide over the stem until resistance is sensed and only then will the bolt tighten and exert the required clamping and sealing force on the combination.

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