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Eye irritation test according to OECD Test Guideline 437

OECD test 437

Curious about how to test if chemical products and cosmetics cause eye irritation without in vivo testing? The Peira LLBO 180 is the preferred instrument approved for OECD Test Guideline 437 to identify ocular corrosives and severe irritants.

The Laser Light-Based Opacitometer (LLBO) measures the opacity of substances in the Bovine Corneal Opacity and Permeability (BCOP) Test Method. This method checks if substances can cause serious eye damage or irritation, using bovine corneas from cattle slaughtered for commercial purposes.

The LLBO complies with OECD Test Guideline 437, proving its reliability in ocular irritation testing. It’s user-friendly, operates independently, and detects opaque spots better. It offers precise rankings of compounds’ eye-irritating potential.

Features

  • OECD Approval: The Peira LLBO 180 is a validated device used for BCOP testing (OECD Test Guideline 437).
  • Mandatory Compliance: One of three opacitometers required by OECD Test Guideline 437.
  • Replacement for OP-KIT: Alternative for OP-KIT and Duratec.
  • Comprehensive Analysis: Analyzes the entire corneal surface.
  • Updated Holders: The internal chamber diameter of the support for LLBO holders is 18 mm, while for OP-KIT, it is 17 mm. 
  • Advanced Equipment: Equipped with a class 3R green laser and standard certified glass filters for calibration.

Why Peira LLBO 180?

Peira LLBO 180
  • OECD Test Guideline 437 Compliance: Fully complies with the OECD Test Guideline 437, confirming its reliability and effectiveness in ocular irritation testing.
  • Stand-Alone Instrument: Operates independently
  • User-Friendly: Easy to use.
  • Enhanced Detection: Better detection of opaque spots around the periphery of the corneas.
  • Accurate Assessment: Provides a more accurate definition of the eye-irritating potential of compounds.
  • Precise Ranking: Offers more precise ranking of moderate to mild and non-irritating compounds.
  • Regulatory Compliance: Ensures adherence to OECD Test Guideline 437.
  • Ethical Testing: Supports non-animal testing methods.

The Peira LLBO 180 enables improved detection of opaque spots around the periphery of the corneas.

Sandra Verstraelen, Senior Researcher, Vito NV

More info

Download the product information brochure or contact us for more information.

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